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NMNAT: It’s an NAD+ synthase, chaperone, AND neuroprotector
Nicotinamide mononucleotide adenylyl transferases (NMNATs) are a family of highly conserved proteins indispensable for cellular homeostasis. NMNATs are classically known for their enzymatic function...
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Sulforaphane a powerful tool to fight cancer, aging, and other inflammatory...
Sulforaphane has been shown to be an effective antioxidant, antimicrobial, anticancer, anti-inflammatory, anti-aging, neuroprotective, and anti-diabetic (R). It also protects against cardiovascular...
View ArticleMitochondrial transplantation: From animal models to clinical use in humans
1. Introduction The importance of the mitochondrion in the maintenance and preservation of cellular homeostasis and function is well established and there is a sufficient body of evidence to show that...
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Enhanced Nutraceutical bioactivity to fight cancer
1. Introduction Nutraceuticals are biologically active molecules found in foods that may not be essential for maintaining normal human functions, but may enhance human health and wellbeing by...
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Sulforaphane increases metabolism to ameliorate obesity and insulin resistance
Study published here: Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice Low-grade sustained inflammation, triggered...
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Rapamycin,rifampicin, Psora-4 cocktail doubles lifespan
Drug combinations work to synergistically extend the life- and healthspan in worms. The most successful drug combination tested almost doubled lifespan, a feat never reported before. Furthermore, more...
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A NAD+/PARP1/SIRT1 axis in Aging
NAD+ levels decline with age in diverse animals from C. elegans to mice [1] [2] [3] [4] [5] and raising NAD+ levels has apparent anti‐aging effects [3] [4] [2] [6] [5]. Increasing NAD+ levels by...
View ArticleSirtuin 6 Improves Healthspan In Mice
Previous research has demonstrated that overexpressing a protein known as SIRT6 increases lifespan of mice and offers protection against obesity-induced metabolic abnormalities. In contrast mice that...
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New Research Discovers Key to Diseases in Mitochondrial DNA Mutations
DNA sequences between mitochondria inside a single cell are vastly different, reported scientists in the Perelman School of Medicine at the University of Pennsylvania. This discovery will help to...
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Fisetin a powerful senolytic that extends health and lifespan
Senescent cells are defective older cells that are no longer functioning as they should. Most are cleared out and recycled by our immune systems, but as we age, more and more of these defective cells...
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